Table 2.
Characteristics of patients according to the FIB4 thresholds.
| FIB-4 | FIB4 < 1.3 (n = 2558) |
FIB4 [1.3, 2.67] (n = 784) |
FIB4 > 2.67 (n = 85) |
P-Value* |
|---|---|---|---|---|
| Age—mean (Sd) [Range] (years) | 51 (17) [76] | 70 (10) [62] | 76 (11) [48] | < 0.0001** |
| Age—N (%) (years) | ||||
| < 65 | 1976 (77%) | 227 (29%) | 14 (16%) | < 0.0001 |
| ≥ 65 | 582 (23%) | 557 (71%) | 71 (84%) | |
| ALT > ULN—N (%) | 187 (7%) | 46 (6%) | 20 (24%) | 0.0421 |
| AST > ULN—N (%) | 167 (7%) | 141 (18%) | 45 (53%) | < 0.0001 |
| Platelets < 150,000—N (%) | 6 (< 1%) | 24 (3%) | 29 (34%) | < 0.0001 |
| AST/ALT ratio > 1—N (%) | 1122 (44%) | 541 (69%) | 69 (81%) | < 0.0001 |
| AST/ALT ratio > 1 in patients with ALT > ULN—N (%) | 1/187 (< 1%) | 4/46 (9%) | 11/20 (55%) | < 0.0001** |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; ULN upper limit of the normal.
*Cochran-Armitage test; **Kruskal–Wallis test.