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. 2024 May 28;15:4529. doi: 10.1038/s41467-024-47218-3

Fig. 3. Definition of functional gene modules associated with SBNO2 gene and isoform expression in human primary MDM.

Fig. 3

a Correlation of the 17 identified WGCNA modules of genes (y-axis) with stimulations, genes, and transcripts of interest (x-axis). Correlation coefficients and p-values are indicated for modules with p-values ≤ 0.05 (Pearson correlation, two-sided test, uncorrected p-values). b MAGMA-based32 gene-set heritability analysis on WGCNA modules for IBD, CD, and UC65. The dot blot illustrates the directionality of association as colour code and the enrichment significance (-log10 p-value) as dot size. Red circular borders around individual dots indicate p-values < 0.05 (one-sided test, uncorrected p-values, as implemented in MAGMA32). c Enrichment of GO pathway terms based on those gene modules that were found correlated with ISO1 (ME9 and ME15), ISO2 (ME12 and ME13), and ISO1 and ISO2 (ME6 and ME14) expression (hypergeometric test, Bonferroni correction, padj < 0.05). Source data are provided as a Source Data file for (b, c).