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. 2024 May 15;5:1352711. doi: 10.3389/fpain.2024.1352711

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© 2024 Kersebaum, Sendel, Lassen, Fabig, Forstenpointner, Reimer, Canaan-Kühl, Gaedeke, Rehm, Gierthmühlen, Baron and Hüllemann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EP correlations within all patients combined. Scatter plots for the significant CEP correlations (which withstood correction for multiple testing) within both patient groups combined. A loss of function indicated by negative CDT Z-scores was associated with a CEP amplitude reduction. A prolonged N2 latency was indicative of higher average and maximum pain as well as stronger tingling sensation and numbness. Interestingly, a CEP amplitude decrease was associated with a functional loss of the autonomic nervous system. As a proof of concept, N2 correlated significantly with height (bottom right). CEP, cold-evoked potential; CDT, cold detection threshold; NRS, numeric rating scale; PDQ, painDETECT questionnaire; RMSSD, root mean square of successive square differences; TDM, time-domain measurement.