Table 2.

Results of multivariable MR estimation of circulating serum metabolites and hemorrhagic stroke.

Type of outcome	Classification	Type/metabolism	nSNP	Methods of multivariable MR	β	SE	p-value	OR (95%CI)
Intracerebral hemorrhage/FinnGen R9	Peptide	Pyroglutamylglycine	101	Multivariable IVW	−0.037	0.232	8.73E-01	0.96 (0.61–1.52)
				Multivariable median	0.164	0.303	5.89E-01	1.18 (0.65–2.13)
				Multivariable egger	0.002	0.234	9.93E-01	1.00 (0.63–1.59)
Intracerebral hemorrhage/FinnGen R7	Cofactors and vitamins	Biliverdin	114	Multivariable IVW	−0.476	0.219	3.01E-02	0.62 (0.40–0.96)
				Multivariable median	−0.510	0.255	4.55E-02	0.60 (0.36–0.99)
				Multivariable egger	−0.448	0.220	4.19E-02	0.64 (0.42–0.98)
Intracerebral hemorrhage/EBI database	Lipid	Linoleate (18:2n6)	105	Multivariable IVW	−1.599	0.503	1.48E-03	0.20 (0.08–0.54)
				Multivariable median	−1.641	0.699	1.88E-02	0.19 (0.05–0.76)
				Multivariable egger	−1.540	0.507	2.38E-03	0.21 (0.08–0.58)
Subarachnoid hemorrhage/FinnGen R9	Peptide	Gamma-glutamylmethionine*	105	Multivariable IVW	0.391	0.417	3.47E-01	1.48 (0.65–3.35)
				Multivariable median	0.066	0.513	8.98E-01	1.07 (0.39–2.92)
				Multivariable egger	0.413	0.416	3.21E-01	1.51 (0.67–3.42)
Subarachnoid hemorrhage/FinnGen R9	Lipid	1-Eicosadienoylglycerophosphocholine*	108	Multivariable IVW	0.792	0.392	4.35E-02	2.21 (1.02–4.76)
				Multivariable median	1.389	0.506	6.07E-03	4.01 (1.49–10.81)
				Multivariable egger	0.840	0.391	3.17E-02	2.32 (1.08–4.99)
Subarachnoid hemorrhage/EBI database		7-Alpha-hydroxy-3-oxo-4-cholestenoate (7-Hoca)	119	Multivariable IVW	−1.322	0.543	1.48E-02	0.27 (0.09–0.77)
				Multivariable median	−1.461	0.740	4.83E-02	0.23 (0.05–0.99)
				Multivariable egger	−1.322	0.543	1.48E-02	0.27 (0.09–0.77)

SE, standard error; OR, odds ratio; SNP, single nucleotide polymorphism.