Table 1.
Anti-HIV-1 integrase activitya of the EtOH extract and fractions from Dioscorea bulbifera.
| Sample | % Inhibition at various concentrations (μg/mL) |
IC50 (μg/mL) | ||||
|---|---|---|---|---|---|---|
| 1 | 3 | 10 | 30 | 100 | ||
| EtOH extract | 5.33 ± 0.73 | 10.11 ± 1.50 | 55.84 ± 0.23 | 72.11 ± 1.75 | 89.25 ± 1.61 | 11.65 |
| CHCl3 fraction | 8.48 ± 0.48 | 19.67 ± 2.58 | 90.83 ± 1.18 | 96.97 ± 1.01 | 102.42 ± 3.26 | 5.42 |
| EtOAc fraction | 1.82 ± 0.81 | 7.70 ± 5.15 | 93.64 ± 0.05 | 97.76 ± 0.76 | 101.21 ± 3.22 | 6.49 |
| H2O fraction | 6.65 ± 0.15 | 10.49 ± 2.64 | 47.48 ± 7.71 | 95.44 ± 0.36 | 98.53 ± 4.04 | 9.12 |
a
Each value represents mean ± SEM of four determinations.