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. 2024 May 7;27(6):109921. doi: 10.1016/j.isci.2024.109921

Figure 2.

Figure 2

mRNA Levels of PIK3CB associate levels of PI3K activation and chemosensitivity in MGMT-deficient GBMs

RNA-seq and RPPA data were retrieved from DepMap and TCGA. The Pearson correlation assay was used to determine associations between two subjects.

(A) Pearson correlations between pAKTS473/T308 and levels of PIK3CA/B/D/G mRNAs in DepMap MGMT-deficient or MGMT-positive GII/III glioma cell lines or GBM cell lines.

(B) Pearson correlations between pAKTS473/T308 and levels of PIK3CA/B/D/G mRNAs in TCGA MGMT-deficient or MGMT-positive GII/III gliomas or GBMs.

(C) Pearson correlations between TMZ IC50s and levels of PIK3CA/B/D/G mRNAs in DepMap MGMT-deficient or MGMT-positive GII/III glioma cell lines or GBM cell lines.

(D) Pearson correlations between TMZ IC50s and levels of pAKTs or PTEN in DepMap MGMT-deficient or MGMT-positive GII/III glioma cell lines or GBM cell lines. Pearson coefficients (r) with 95% confidence intervals (95% CI) are shown. Representative Pearson correlation results in MGMT-deficient GBMs are also shown. Original results of Pearson correlation in other gliomas are shown in Figures S7, S8, S10, and S11. ∗: p < 0.05; ∗∗: p < 0.01. Statistically not significant Pearson coefficients are not labeled.