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. 2024 May 29;14(23):16349–16357. doi: 10.1039/d4ra00557k

IC50 of compounds 13a, 13b, and 13d–13f.

Compound IC50 (μM)
NO IL-6 TNF-α
DEX 21.197 ± 0.517 0.247 ± 0.073 27.796 ± 0.643
13a 61.494 ± 0.560 1.437 ± 0.351 62.835 ± 1.198
13b 10.992 ± 0.328 2.294 ± 0.791 12.901 ± 1.591
13d 19.969 ± 0.674 4.715 ± 1.995 22.044 ± 0.449
13e 22.143 ± 1.019 4.879 ± 0.112 21.795 ± 1.143
13f 36.041 ± 1.375 1.539 ± 0.515 46.777 ± 0.197