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. Author manuscript; available in PMC: 2024 May 29.
Published in final edited form as: J Eur Acad Dermatol Venereol. 2022 Oct 5;37(1):166–175. doi: 10.1111/jdv.18616

FIGURE 5.

FIGURE 5

Functional profiles show active metabolic state in late acne skin. (a) PCA plot illustrating functional composition of all four groups; generated by MicrobiomeAnalyst; circles are 95% confidence intervals for respective datasets. (b) Ten metabolic pathways and the number of significant enzymes out of the total number of enzymes affiliated with each pathway. Pathways marked with an * and in bold text are significant by Kruskal-Wallis FDR <0.05. (c) Heatmap showing the 16 significant enzymes associated with KEGG pathway: Porphyrin and chlorophyll metabolism. Heatmap represents high (red) and low (blue) expression of each individual enzyme of the four groups. (d) Heatmap of the 10 significant enzymes associated with histidine metabolism. (e) Heatmap of the seven significant enzymes associated with propanoate metabolism.