Figure 1.

Tregitope-adjusted Immunogenicity Risk Potential Scores of RA Biologics and Benchmark Proteins. The EpiMatrix Tregitope-adjusted Protein Immunogenicity Risk Potential Score represents the aggregate predicted T cell epitope content in each protein, per unit protein length, relative to the expected T cell epitope content in a protein of equivalent length. Proteins with positive scores carry more epitope content than the random expectation, and thereby, increased risk for immunogenic response. Proteins with negative scores carry less epitope content than random expectation, and reduced risk for immunogenic response. These scores are adjusted for the presence of epitopes known to stimulate regulatory T cells, called Tregitopes. Human proteins have a wide distribution of Immunogenicity Risk Potential Scores, whose median is -9.05. The median Immunogenicity Risk Potential Score of secreted human proteins is even lower, at -23.08. Protein Immunogenicity Risk Potential Scores above the median of the human proteome may indicate elevated immunogenic risk for therapeutic protein candidates.