Fig. 1.

Flow diagram of cohort selection. After applying the inclusion and exclusion criteria, we ultimately obtained 147 samples, including 73 high-risk samples and 74 low-risk samples. The number of cases in the high-risk and low-risk groups was sampled to be evenly distributed by chance. The dataset was stratified at a ratio of 8:2, with 117 samples in the training set. As 117 is an odd number, the training set included 58 high-risk and 59 low-risk samples. The test set consisted of 30 samples, with an equal number of high-risk and low-risk samples, each being 15