Fig. 1.

Overview of phuEGO’s methodology. PhuEGO first starts by performing a (up-to) three-layer random-walk-with restart on an integrated protein interaction network. It then re-maps the seed nodes as ‘egos’ and identifies a local network or module that comprises nodes that are most topologically and functionally similar to the ego. Finally, by combining these modules phuEGO generates a network of supernodes that include overlapping functional modules.