Fig. 3.

The expression of HIF-1α-target genes is increased in the livers ofSirt1^−/−mice. Immunoblot analysis of (A) NQO1 and (B) HIF-1α in the livers of WT and Sirt1^−/− mice. mRNA levels of (C) Glut1 and (D) Vegfa in the livers of WT and Sirt1^−/− mice. Data are presented as the mean ± SEM. Significant differences were established by Student’s t-test. *p < 0.05 and **p < 0.01 vs. CT. n = 4 per group