Table 1.
Selection of currently recruiting studies investigating the relationship of sleep and stroke (reference clinicaltrials.gov).
| ClinicalTrials.gov identifier | Investigation | N, year completed |
|---|---|---|
| Observational | ||
| NCT03274505 | Prevalence of sleep disorders in transient ischemic attack and stroke. | N = 200, 2023 |
| NCT05242393 | Association of circadian rhythm disorder and outcome 14 days poststroke. | N = 250, 2024 |
| NCT05012605 | Impact of non-OSA sleep disorders on ADL, functional mobility, and recovery of stroke patients. | N = 200, 2025 |
| NCT04312126 | Investigate the role of memory replay during wakeful rest and sleep (naps) in retaining newly learned skills poststroke. | N = 138, 2025 |
| NCT05746260 | Association of sleep disruption and clinical motor outcomes. | N = 150, 2027 |
| Interventional | ||
| NCT03812653 | Whether CPAP treatment for sleep apnea initiated acutely after stroke improves functional outcome and reduces stroke recurrence. | N = 3062, 2023 |
| NCT05867290 | Effect of mindful music listening on subjective and objective insomnia symptoms as well as mood and fatigue poststroke. | N = 6, 2023 |
| NCT04876001 | Effect of nurse-led brief behavior therapy for poststroke insomnia. | N = 60, 2023 |
| NCT05511285 | Efficacy of digital cognitive behavioral therapy in comparison with usual care alone for reducing insomnia symptoms after stroke. | N = 100, 2024 |
| NCT05247125 | Influence of combined blue light exposure and melatonin therapy on molecular biomarkers of circadian rhythms, sleep characteristics, and stroke outcome in acute stroke patients. | N = 80, 2024 |
| NCT05623137 | Effect of transcutaneous electrical nerve stimulation at acupoints on sleep quality, motor function, and cognition in older adult participants with chronic stroke. | N = 70, 2024 |
| NCT02554487 | Effect of early treatment of sleep apnea with adaptive servoventilation on the evolution of stroke lesion volume and clinical outcomes. | N = 201, Unknown |
| NCT05289518 | Effect of remote ischemic conditioning on stroke-related insomnia. | N = 136, Unknown |
| NCT05170386 | Effect of cognitive training on poststroke sleeping disorders. | N = 40, Unknown |
OSA: obstructive sleep apnea; CPAP: continuous positive airway pressure; ADL: activity of daily living.