Table 3.
Correlations between c-mesenchymal-epithelial transition factor protein expression and clinicopathological characteristics of colorectal cancer patients, n (%)
| Characteristic |
C-MET IHC
|
P value | |||
|
0/1+ (n = 54)
|
2+ (n = 112)
|
3+ (n = 39)
|
Total (n = 205)
|
||
| Gender | 0.525 | ||||
| Male | 33 (61.1) | 58 (51.8) | 21 (53.8) | 112 (54.6) | |
| Female | 21 (38.9) | 54 (48.2) | 18 (46.2) | 93 (45.4) | |
| Age (yr) | 0.138 | ||||
| ≥ 60 | 33 (61.1) | 51 (45.4) | 22 (56.4) | 106 (51.7) | |
| < 60 | 21 (38.9) | 61 (54.5) | 17 (43.6) | 99 (48.3) | |
| Primary site | 0.805 | ||||
| Colon | 38 (70.4) | 77 (68.8) | 25 (64.1) | 140 (68.3) | |
| Rectum | 16 (29.6) | 35 (31.3) | 14 (35.9) | 65 (31.7) | |
| Tumor type | 0.656 | ||||
| Exophytic type | 39 (72.2) | 81 (72.3) | 31 (79.5) | 151 (73.7) | |
| Ulcerative type | 15 (27.8) | 31 (27.7) | 8 (20.5) | 54 (26.3) | |
| LVI | 0.941 | ||||
| Present | 17 (31.5) | 34 (30.4) | 13 (33.3) | 64 (31.2) | |
| Absent | 37 (68.5) | 78 (69.6) | 26 (66.7) | 141 (68.8) | |
| PNI | 0.897 | ||||
| Present | 15 (27.8) | 33 (29.5) | 10 (25.6) | 58 (28.3) | |
| Absent | 39 (72.2) | 79 (70.5) | 29 (74.4) | 147 (71.7) | |
| EMVI | 0.252 | ||||
| Present | 5 (9.3) | 21 (18.8) | 5 (12.8) | 31 (15.1) | |
| Absent | 49 (90.7) | 91 (81.3) | 34 (87.2) | 174 (84.9) | |
| LNM | 0.002 | ||||
| Present | 18 (33.0)1 | 56 (50.0)1 | 25 (64.1)1 | 89 (43.4) | |
| Absent | 36 (67.0)1 | 56 (50.0)1 | 14 (35.9)1 | 116 (56.6) | |
| PDC | 0.188 | ||||
| Present | 35 (64.8) | 87 (77.7) | 30 (76.9) | 152 (74.1) | |
| Absent | 19 (35.2) | 25 (22.3) | 9 (23.1) | 53 (25.9) | |
| TB | 0.148 | ||||
| BD1 | 34 (63.0) | 66 (58.9) | 17 (43.6) | 117 (57.1) | |
| BD2/3 | 20 (37.0) | 46 (41.1) | 22 (56.4) | 88 (42.9) | |
| Histologic differentiation | 0.541 | ||||
| P/D or mucinous | 17 (31.5) | 27 (24.1) | 9 (23.1) | 53 (25.9) | |
| W/D or M/D | 37 (68.5) | 85 (75.9) | 30 (76.9) | 152 (74.1) | |
1
Each superscript letter denotes a subset of MET mesenchymal-epithelial transition factor immunohistochemistry categories whose column proportions do not differ significantly from each other at the 0.05 level.
MET: Mesenchymal-epithelial transition factor; EMVI: Extramural venous invasion; LNM: Lymph node metastasis; LVI: Lymphovascular invasion; M/D: Moderately differentiated; P/D: Poorly differentiated; PDC: Poorly differentiated clusters; PNI: Perineural invasion; TB: Tumor budding; W/D: Well differentiated.