Table 3.

Univariate and multivariate analysis of disease-free survival in patients with ampullary adenocarcinoma

Variate	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Gender (male vs female)	0.945	0.653-1.367	0.764
Age (≤ 60 vs > 60)	1.048	0.723-1.518	0.806
Tumor size (≤ 2 vs > 2)	1.213	0.844-1.745	0.297
Tumor differentiation (non-well vs well)	0.666	0.420-1.056	0.084
Lymph nodes resection (< 17 vs ≥ 17)	1.061	0.711-1.583	0.771
Vascular invasion (No vs Yes)	1.523	1.012-2.291	0.044	1.063	0.677-1.668	0.792
pT (T1, T2 vs T3, T4)	1.975	1.363-2.861	< 0.001	1.819	1.215-2.723	0.004
pN (N0 vs N1, N2)	2.113	1.440-3.101	< 0.001	1.793	1.130-2.846	0.013
Postoperative complication (No vs Yes)	1.022	0.701-1.491	0.909
Postoperative adjuvant therapy (No vs Yes)	1.591	1.072-2.360	0.021	0.958	0.590-1.557	0.863
PNI (< 45.3 vs ≥ 45.3)	0.631	0.438-0.909	0.013	0.674	0.464-0.980	0.039

PNI: Prognostic nutritional index; 95%CI: 95% confidence interval; HR: Hazard ratio.