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. 2024 May 21;30(19):2575–2602. doi: 10.3748/wjg.v30.i19.2575

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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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SLC16A1 promotes L-lactylation in pancreatic cancer. A: L-lactylation levels in normal and pancreatic ductal adenocarcinoma (PDAC) cell lines; B and C: Intracellular lactate and western blotting of lactylation under different concentration of lactate; D: Expression of lactylation-related genes (LRGs) in normal and PDAC cell lines; E: Expression of SLC16A1 in normal and PDAC cell lines; F-G: Intracellular lactate and western blotting of lactylation treated with different concentration of α-cyano-4-hydroxycinnamic acid (CHC); H: Expression of histone L-lactylation in pancreatic cancer treated with lactate and CHC. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. CHC: Α-cyano-4-hydroxycinnamic acid; PDAC: Pancreatic adenocarcinoma.