Table 3. Demographic and clinical characteristics by presence of meningeal enhancement in the MS cohort.
| LME | PDE | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gd+ 3T LME + N = 14 | Gd+ 3T LME—N = 46 | Gd+ Early 7T LME + N = 45 | Gd+ Early 7T LME—N = 50 | Gd+ Delayed 7T LME + N = 55 | Gd+ Delayed 7T LME—N = 40 | Gd+ 3T PDE + N = 39 | Gd+ 3T PDE—N = 21 | Gd+ Early 7T PDE + N = 82 | Gd+ Early 7T PDE—N = 13 | Gd+ Delayed 7T PDE + N = 92 | Gd+ Delayed 7T PDE—N = 3 | ||
| Mean Age (SD) | 47.21 (10.8) | 44.39 (9.93) | 45.8 (10.0) | 44.7 (11.0) | 47.6* (10.6) | 42.0* (9.7) | 46.6 (10.0) | 42.1 (10.0) | 45.7 (10.6) | 42.7 (10.4) | 45.3 (10.4) | 42.7 (16.2) | |
| Median Disease Duration [min-max] | 14.2 [5.3–29.4] | 12.5 [0.4–33.3] | 11.2 [1.7–47.8] | 12.4 [0.4–33.3] | 11.8 [0.4–47.8] | 10.1 [1.5–24.7] | 14.2 [1.8, 33.3] | 11.8 [0.4, 24.2] | 10.7 [1.2–47.8] | 12.6 [0.4, 22.9] | 11.3 [0.4–47.8] | 12.6 [1.8–17.9] | |
| Female Gender (%) | 12 (85.7) | 29 (63.0) | 30 (66.7) | 36 (72.0) | 39 (70.9) | 27 (67.5) | 30 (76.9) | 11 (52.4) | 56 (68.3) | 10 (76.9) | 64 (69.6) | 2 (66.7) | |
| Disability Scales | Median EDSS [min-max] | 2.3 [1.5–6.5] | 2.5 [0–6.5] | 2.5 [0–6.5] | 3 [0–6.5] | 2.5 [0–6.5] | 2.5 [0–6.5] | 2.5 [0–6.5] | 2.5 [0–6.5] | 2.5 [0–6.5] | 2.5 [0–6.5] | 2.5 [0–6.5] | 4 [1.5–6] |
| Median 9HPT [min-max] | 5.1 [3.9–161] | 4.9 [3.7–161] | 5 [3.2–161] | 5.4 [3.4–161] | 5.5 [3.2–161] | 5.1 [3.4–161] | 4.9 [3.7–161] | 5.2 [3.9–161] | 5.3 [3.2–161] | 5.1 [3.8–24.1] | 5.3 [3.2–161] | 6.4 [4.5–8.2] | |
| Median T25W [mix-max] | 5.1 [3.9–161] | 4.9 [3.7–161] | 5.0 [3.2–161] | 5.4 [3.4–161] | 5.5 [3.2–161] | 5.1 [3.4–161] | 4.9 [3.7, 161] | 5.2 [3.9–161] | 5.3 [3.2–161] | 5.1 [3.8, 24.1] | 5.3 [3.2–161] | 6.4 [4.5–8.2] | |
| Mean SDMT (SD) | 54.6 (15.0) | 53.8 (14.9) | 54.4 (15.5) | 53.4 (14.8) | 54.9 (14.7) | 52.8 (15.5) | 54.0 (16.0) | 54.0 (12.6) | 53.7 (15.1) | 55.5 (15.5) | 54.1 (15.0) | 47.7 (20.0) | |
| Median PASAT [min-max] | 48.5 [0–55] | 48 [0–59] | 46 [0–59] | 44.5 [7–60] | 43 [0–59] | 45.5 [6–60] | 48 [0–59] | 49 [26–56] | 45 [0–60] | 43 [24–56] | 45 [0–60] | 49 [42–56] | |
LME = leptomeningeal enhancement, PDE = paravascular/dural enhancement, SD = standard deviation. EDSS = Expanded Disability Status Scale, 9HPT = Nine Hole Peg Test (in seconds), T25W = Timed 25-foot walk (in seconds), SDMT = Symbol Digit Modalities Test (# correct).
Wilcoxon rank sum test was used for all values shown as median, t-test for those shown as mean, and proportions were tested by Chi-square or Fisher’s exact test.
“*” = p < 0.05.