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. 2024 May 29;19(5):e0302998. doi: 10.1371/journal.pone.0302998

Fig 1. Schedule of enrollment, interventions, and assessments.

Fig 1

Abbreviations: ECG, electrocardiogram; TSH, thyroid stimulating hormone; PK, pharmacokinetic; PD, pharmacodynamic; AGE, advanced glycation end products; ThDP, thiamine diphosphate; ThMP, thiamine monophosphate; Nfl, neurofilament light chain; GFAP, glial fibrillary acidic protein; Aβ, beta-amyloid; MRI, magnetic resonance imaging; CSF, cerebrospinal fluid; LP, lumbar puncture; CAGE-AID, CAGE Adapted to Include Drugs; C-SSRS, Columbia Suicide Severity Rating Scale; MoCA, Montreal Cognitive Assessment; MMSE, Mini-Mental State Examination; CDR, Clinical Dementia Rating; ADAS-Cog13, Alzheimer’s Disease Assessment Scale-Cognitive Subscale 13; ADCS-ADL-MCI, Alzheimer’s Disease Cooperative Study–Activities of Daily Living Scale for use in Mild Cognitive Impairment; NPI, Neuropsychiatric Inventory; IP, investigational product.