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. 2023 Nov 15;20(5):1015–1031. doi: 10.1080/15548627.2023.2281134

Figure 1.

Figure 1.

Aerobic exercise ameliorates cognitive dysfunction in APP-PSEN1 mice. (A) schematic of the experimental procedure for the AE and behavioral tests. (B) escape latency to the hidden platform between days 1 and 5. (C) area under the curve (AUC) of fig. 1B. (D) swimming pathway traveled to locate the platform on day 6. (E) the escape latency, (F) number of crossings of the original position of the platform, (G) traveled distance and (H) swimming speed on day 6. (I) schematic of contextual fear freezing test methods. (J-M) effect of AE on the foot shock-induced contextual fear freezing test. n = 15 mice per group in MWM test and n = 10 mice per group in contextual fear freezing test. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. The data are presented as the means ± SEMs. Two-way repeated-measures ANOVA followed by Bonferroni’s post hoc test was used to analyze the data in (B), and one-way ANOVA followed by Bonferroni’s post hoc test was used to analyze the data in (C-M).