Figure 2.

Aerobic exercise ameliorates amyloid-β pathology in APP-PSEN1 mice. (A) Representative images of Aβ plaques by 4G8 staining and thioflavin S staining. (B and C) quantification of the percentage of area occupied by Aβ plaques in the hippocampus and cortex. (D) the amount of soluble Aβ fractions extracted from the hippocampus was examined by western blot analysis. (E) quantification of soluble Aβ intensity using ImageJ. (F) insoluble Aβ detected by ELISA kit. n = 6 mice per group. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. The data are presented as the means ± SEMs. Student’s t tests were used to analyze the data in (B-F), and two-way ANOVA followed by Bonferroni’s post hoc test was used to analyze the data in (H).