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. 2024 May 29;84(5):443–458. doi: 10.1055/a-2286-6066

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The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

PMC Copyright notice

Abb. 7 — Effekt einer ESR1 -Mutation auf die Funktionsweise des Östrogenrezeptors (unter Creative Commons Lizenz 4.0, 59 ). LBD: ligandenbindende Domäne, AF-2: Activating Factor-2 Domäne, DBD: DNA-bindende Domäne, AF-1: Activating Factor 1-Domäne, E2: Östradiol, SERM: selektiver Östrogenrezeptor-Modulator, SERD: selektiver Östrogenrezeptor-Degradierer, WT: Wildtyp, MUT: mutiert (Quelle: Brett JO, Spring LM, Bardia A et al. ESR1 mutation as an emerging clinical biomarker in metastatic hormone receptor-positive breast cancer. Breast Cancer Res 2021; 23: 85. doi:10.1186/s13058-021-01462-3 . © 2021. The Author(s). Licensed under a Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/ ). Changes: Addition of explanations for WT and MUT in the image.