Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 May 29;84(5):443–458. doi: 10.1055/a-2286-6066

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

PMC Copyright notice

Fig. 7 — Effect of ESR1 mutation on the function of the estrogen receptor (Creative Commons Licence 4.0, 59 ). LBD: ligand-binding domain, AF-2: activating factor-2 domain, DBD: DNA-binding domain, AF-1: activating factor 1 domain, E2: estradiol, SERM: selective estrogen receptor modulator, SERD: selective estrogen receptor degrader, WT: wildtype, MUT: mutated (Source: Brett JO, Spring LM, Bardia A et al. ESR1 mutation as an emerging clinical biomarker in metastatic hormone receptor-positive breast cancer. Breast Cancer Res 2021; 23: 85. doi:10.1186/s13058-021-01462-3.) © 2021. The Author(s). Licensed under a Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/ ). Changes: Addition of explanations for WT and MUT in the image.