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. 2024 May 15;629(8014):1133–1141. doi: 10.1038/s41586-024-07419-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 12 — a-n, Brain nuclei for bulk RNA sequencing of the brainstem came from mice in Fig. 3h, i and Extended Data Fig. 8 treated with 100 nmol kg⁻¹ MK-801 (n = 8 mice), 100 nmol kg⁻¹ GLP-1 (n = 8 mice), 100 nmol kg⁻¹ GLP-1–MK-801 (n = 8 mice) or vehicle (isotonic saline, n = 8 mice) for 5 days. a, Schematic. b, Schematic highlighting the brainstem. c, Venn diagram of differentially expressed genes in response to treatments. d, Volcano plot for differentially expressed genes in response to GLP-1–MK-801. e, Top five most enriched functional terms for the 3594 differentially expressed genes between GLP-1–MK-801 and vehicle. f, Top five most enriched functional terms for the 2076 differentially expressed genes that were upregulated in response to GLP-1–MK-801 treatment relative to vehicle. g, Top five most enriched functional terms for the 1518 differentially expressed genes that were downregulated following GLP-1–MK-801 treatment relative to vehicle. h, Top eleven cellular component and top three biological process functional terms identified using gene set enrichment (GSEA) analysis. i, Venn diagram showing the overlap with the SynGO database and the 3594 differentially expressed genes in response to GLP-1–MK-801. j, Sunburst plot of differentially expressed genes belonging to cellular component functional terms computed with SynGO. Enrichment is colour coded by Q value for the functional terms. All level terms identified have been labelled. k, Sunburst plot of differentially expressed genes belonging to biological process functional terms computed with SynGO. Enrichment is colour coded by Q value for the functional terms. All level terms identified have been labelled. l, Schematic highlighting the nucleus accumbens. m, Venn diagram of differentially expressed genes in response to treatments. n, Volcano plot for differentially expressed genes of GLP-1–MK-801. Benjamini-Hochberg adjusted P (c-n). Detailed statistics are in Supplementary Table 1. The diagrams in a-c, i, l and m were created using BioRender.

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