Table 1.
Descriptive analysis of GLP-1a and DPP-4i users
| GLP-1a (n = 11,745) |
DPP-4i (n = 24,370) |
Total (n = 36,115) | |
|---|---|---|---|
| Mean age (± SD) | 67.2 (± 5.8) | 71.0 (± 8.1) | 69.7 (± 7.6) |
| HbA1c (mmol/mol)—mean (± SD) | 67.9 (± 16.5) | 62.1 (± 16.1) | 63.9 (± 16.3) |
| HbA1c—latest measurement prior to the index date—median (days) | 19 | 27 | 21 |
| Sex, n (%) | |||
| Males | 6898 (58.7) | 13,945 (57.2) | 20,843 (57.7) |
| Females | 4847 (41.3) | 10,425 (42.8) | 15,272 (42.3) |
| Drugs (ATC code), n (%) | |||
| Exenatide (A10BJ01) | 1027 (8.7) | 1027 (2.8) | |
| Liraglutide (A10BJ02) | 10,718 (91.3) | 10,718 (29.7) | |
| Sitagliptin (A10BH01) | 16,961 (69.6) | 16,961 (47.0) | |
| Vildagliptin (A10BH02) | 2915 (12.0) | 2915 (8.1) | |
| Saxagliptin (A10BH03) | 1536 (6.3) | 1536 (4.3) | |
| Alogliptin (A10BH04) | 228 (0.9) | 228 (0.6) | |
| Linagliptin (A10BH05) | 2730 (11.2) | 2730 (7.6) | |
| Educational level | |||
| No education | 47 (0.4) | 91 (0.4) | 138 (0.4) |
| Compulsory school and 10th grade | 4,733 (41.4) | 10,717 (45.7) | 15,450 (44.3) |
| Vocational education and training and adult education | 257 (2.2) | 576 (2.5) | 833 (2.4) |
| Upper secondary certificate (gymnasium) | 282 (2.5) | 658 (2.8) | 940 (2.7) |
| Academic profession degrees | 4187 (36.6) | 8004 (34.1) | 12,191 (34.9) |
| Bachelor and diploma degree | 1075 (14.9) | 2926(12.5) | 4631(13.3) |
| Candidatus and master’s degree | 159 (1.4) | 332 (1.4) | 491 (1.4) |
| PhD | 19 (0.2) | 30 (0.1) | 49 (0.1) |
| Other | 54 (0.5) | 126 (0.5) | 180 (0.5) |
| Comorbidities n (%) | |||
| Hypertension | 8982 (76.5) | 17,276 (70.9) | 26,258 (72.7) |
| Traumatic brain injury | 354 (3.0) | 753 (3.1) | 1107 (3.1) |
| Schizophrenia | 24 (0.2) | 81 (0.3) | 105 (0.3) |
| Major depression | 1826 (15.5) | 3478 (14.3) | 5304 (14.7) |
| Bipolar disorders | 28 (0.2) | 51 (0.2) | 79 (0.2) |
| Ischemic heart disease | 3530 (30.1) | 6518 (26.7) | 10,048 (27.8) |
| Cerebrovascular disease | 1274 (10.8) | 3281 (13.5) | 4555 (12.6) |
| Obesity | 3555 (30.3) | 6614 (14.8) | 7169 (19.9) |
| Hypercholesterolemia | 9624 (81.9) | 18,447 (75.7) | 28,071 (77.7) |
| Infection | 5854 (49.8) | 11,707 (48.0) | 17,561 (48.6) |
| COPD | 1980 (16.9) | 3850 (15.8) | 5830 (16.1) |
| Inflammatory disease | 1559 (13.3) | 3224 (13.2) | 4783 (13.2) |
| Alcohol use disorder | 377 (3.2) | 857 (3.5) | 1234(3.4) |
ATC Anatomical Therapeutic Chemical system code, COPD chronic obstructive pulmonary disease, DPP-4i dipeptidyl peptidase-4 inhibitors, GLP-1a glucagon-like peptide-1 analogues