Table 2.

Univariate and multivariate cox regression for major and mild cognitive impairment

Outcome	Drug classes	N. events (%)	Crude HR (95% CI)	Adjusted HR (95% CI)
Major cognitive impairment	GLP-1a (Ref. group)	81 (0.7)	–	–
	DPP-4i	444 (1.8)	3.13 (2.45–4.00)	1.58 (1.22–2.06)
Mild cognitive impairment	GLP-1a (Ref. group)	25 (0.2)	–	–
	DPP-4i	54 (0.2)	1.62 (0.97–2.71)	1.32 (0.75–2.33)

HR hazard ratio, CI confidence interval, DPP-4i dipeptidyl peptidase-4 inhibitors, GLP-1a glucagon-like peptide-1 analogues