Table 1.
Characteristics of patients with 8p11.2 translocations
| Patient number | Age/Sex | Karyotypes | FISH | Diagnosis associated with 8p11.2 translocation | Absolute cell count (× 109/L) | Antecedent disease | Subsequent transformation | |
|---|---|---|---|---|---|---|---|---|
| Eosinophils | Monocyte | |||||||
| 1 | 70/F | 46, XX, t(8;15)(p11.2;q11.2), t(14;18)(q32;q21) [2] | n.d | Follicular lymphoma grade 3A | 0.2 | 0.26 | ||
| 2 | 61/M |
46, XY, t(8;13)(p11.2;q12) [4] 46, XY [16] |
split signal | AITL | 2.8 | 1.9 | MDS/MPN, AML | |
| 3 | 48/F |
46, XX, t(8;16)(p11.2;p13.3) [18] 46, XX [2] |
n.d | AML M5b | 0.2 | 0.28 | ||
| 4 | 69/F |
46, XX, t(1;7;8)(p13;q32;p11.2), t(6;9)(p21;p24), add(13)(q32) [4] 46, XX, idem, add(4)(p11) [7] 46, XX [9] |
no split signal | DLBCL | 0.09 | 0.62 | ||
| 5 | 70/F |
46, XX, t(8;13)(p11.2;q12) [18] 46, XX [2] |
split signal | T-LBL | 19.9 | 2.3 | aCML | |
| 6 | 55/M | 48, XY, t(8;13)(p11.2;q12), + der(13)t(8;13), + 21 [17] | split signal | MLN-FGFR1 translocation, T-lymphoblastic leukemia/lymphoma | 5.2 | 4.6 | AML | |
| 7 | 73/M |
59, XY, -X, dic (1;8)(p13;p11.2), -6, add(7)(p15), -8, -10, -12, -13, add(14)(q32), + add(15)(q22),-16, -17, -18, + 19, -20, -22 [2] 59, XY, -X, dic (1;8)(p13;p11.2), -6, add(7)(p15), -8, -10, -12, -13, + add(15)(q22), -16, -17, -18, + 19, -20, -21, -22, + mar [2] 58, XY, -X, dic (1;8)(p13;p11.2), -6, add(7)(p15), -8, -10, -12, -13, + add(15)(q22), -16, -17, -18, -18, + 19, -20, -21, -22, + mar [1] 58, XY, -X, dic (1;8)(p13;p11.2), -6, add(7)(p15), -8, -10, -12, -13, + add(15)(q22), -16, -17, -18, + 19, -20, -21, -22 [1] 46, XY [14] |
n.d | Multiple myeloma | 0.1 | 3.1 | ||
| 8 | 72/M |
46, XY, der(8)t(1;8)(q12;p11.2), t(10;14)(p11.2;q32) [2] 46, idem, -16, + 22 [1] 46, XY [17] |
n.d | NHL, marginal zone lymphoma | 0.08 | 0.16 | ||
| 9 | 53/F |
43, XX, der(3)t(1;3)(q25;p13),-7, dic(8;?)(p11.2;?), -15, -18 [8] 61, idem, + 1, + 2. + 2, + 3, + 6, + 6, + 7, + 8, + i(8)(q10), + 14, + 14, + 15, + 16, + 18, + 19, + 19, + 20, + 20, + 21 [3] |
3 signals | Acute erythroblast leukemia | 0.06 | 0.7 | MDS | |
| 10 | 59/M | 46, XY, idic(8)(p11.2), t(9;22)(q34;q11.2) [20] | n.d | Ph-positive ALL | 0 | 0.03 | ||
Abbreviations: FISH, fluorescence in situ hybridization; N.D., not done; AITL, angioimmunoblastic T-cell lymphoma; AML, acute myeloid leukemia; DLBCL, diffuse large B-cell lymphoma; T-LBL, T-cell lymphoblastic lymphoma/lymphoma; MLN-FGFR1, myeloid and lymphoid neoplasms associated with FGFR1 abnormalities; NHL, non-Hodgkin’s lymphoma; Ph, Philadelphia chromosome; ALL, acute lymphoblastic leukemia; aCML, atypical chronic myeloid leukemia; MDS, myelodysplastic syndrome