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. 2024 Feb 3;51(3):227–242. doi: 10.1007/s10928-023-09898-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Visual predictive checks of the final PopPK model stratified by study. A NCT01418963; B NCT03586726 (10 mg) and NCT03579719 (5 mg); C NCT01793441 (VANILLA) and NCT02901431 (aV1ation). Median, 5th and 95th percentiles of observed data (solid and dashed lines) are overlain to the simulated 95% confidence intervals (shaded areas). A VPC versus time since last dose for Study NCT01418963 day 1 (left panel) and day 13 (right panel); B VPC versus time since first dose for the steady-state PK profiles in NCT03586726 (10 mg, upper panel) and NCT03579719 (5 mg, lower panel); C prediction-corrected VPC versus time since last dose for the steady-state PK profiles in NCT01793441 (VANILLA, left panel) and NCT02901431 (aV1ation, right panel)