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. 2024 Feb 3;51(3):227–242. doi: 10.1007/s10928-023-09898-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Effect of age on apparent clearance. Solid line shows proportion of adult mean CL/F modeled by an asymptotic function (see text) based on population mean parameter estimates AGE_slope (0.267) and AGE₅₀ (5.35 years; age at 50% of adult clearance). Shaded area represents uncertainty in the age–clearance relationship derived from the 95% CI around AGE₅₀ (1.4–6.9 years). Dashed lines represent 50% and 90% of adult CL/F