Table 5.
Characterization of patients with serum NfL in the highest quartile
| All patients n = 99 |
4th quartile serum NfL, >17.5 pg/ml n = 24 |
4th quartile serum GFAP, >109 pg/ml n = 24 |
Serum NFL > 10.0 pg/ml n = 55 |
Combined 4th quartile serum NfL and 4th quartile serum GFAP n = 9 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Age (years), mean (SD) | 34.0 (± 9.5) | 33.9 (± 10.3) | 33.9 (± 10.3) | 33.9 (± 9.3) | 34.1 (± 11.5) | |||||
| Female, n (%) | 77 | 77.7% | 21 | 87.5% | 21 | 87.5% | 44 | 80% | 8 | 88.9% |
| Male, n (%) | 22 | 22.2% | 3 | 12.5% | 3 | 12.5% | 11 | 20% | 1 | 11.1% |
| RRMS, n (%) | 77 | 77.7% | 24 | 100% | 22 | 91.7% | 47 | 85.5% | 9 | 100% |
| CIS, n (%) | 22 | 22.2% | 0 | 0.0% | 2 | 8.3% | 8 | 14.5% | 0 | 0.0% |
| BMI (kg/m2), mean (SD) | 25.0 (± 5.2) | 25.0 (± 6.1) | 25.0 (± 6.1) | 24.6 (± 5.6) | 22.1 (± 4.3) | |||||
| EDSS, mean (SD) | 1.9 (± 1.2) | 2.1 (± 1.3) | 2.1 (± 1.3) | 2.0 (± 1.2) | 2.5 (± 1.4) | |||||
| Gadolinium-enhancing T1-weighted lesions on MRI, n (%) | ||||||||||
| Yes | 58 | 58.5% | 21 | 87.5% | 16 | 66.7% | 37 | 67.3 | 7 | 77.8% |
| No | 35 | 35.4% | 2 | 8.3% | 7 | 29.2% | 15 | 27.3 | 1 | 11.1% |
| Gd not administered | 6 | 6.1% | 1 | 4.2% | 1 | 4.2% | 3 | 5.5 | 1 | 11.1% |
| With acute relapse, n (%) | 86 | 86.9% | 22 | 91.7% | 24 | 100% | 50 | 90.1% | 9 | 100% |
| Blood-CSF barrier dysfunction, n (%) | 19 | 19.2% | 6 | 25.0% | 3 | 12.5% | 10 | 18.2% | 7 | 22.2% |
| CSF leucocytes count (/mm3), mean (SD) | 9.9 (± 12.6) | 12.7 (± 8.7) | 12.8 (± 8.7) | 10.2 (± 8.8) | 13.6 (± 11.7) | |||||
| Intrathecal synthesis of IgG, n (%) | 60 | 60.6% | 19 | 79.2% | 17 | 70.8 | 34 | 61.8% | 7 | 77.8% |
| Positive oligoclonal bands, n (%) | 90 | 90.9% | 24 | 100% | 24 | 100% | 51 | 92.3% | 9 | 100% |
| CSF/blood albumin quotient, mean (SD) | 5.0 (± 2.1) | 5.3 (± 2.0) | 5.3 (± 2.0) | 5.1 (± 2.1) | 5.5 (± 2.0) | |||||
RRMS relapsing–remitting multiple sclerosis, CIS clinically isolated syndrome, EDSS Expanded Disability Status Scale, Gd gadolinium, MRI magnetic resonance imaging, CSF cerebrospinal fluid, IgG immunoglobulin G, NfL neurofilament light, GFAP glial fibrillary acidic protein, SD standard deviation
Demographic, clinical and laboratory characteristics of patients with serum NfL in the highest quartile (above 17.5 pg/nL) in comparison to all patients