Table 2.
Differentially expressed (DE) orthologs between Coelioxoides waltheriae and Tetrapedia diversipes grouped according to their association to the top enriched GO terms for Cell Component and Molecular Function categories.
| DEO IDs | Expression patterns | Homologs (Swiss-Prot organism) | GO hierarchical groups |
|---|---|---|---|
| Calcium channels | |||
| OG0000284 |
C. waltheriae ↓ T. diversipes ↑ |
CAC (Apis mellifera) |
Cell component GO1 ion channel complex GO2 transporter complex GO3 plasma membrane protein complex Molecular function GO1 channel activity GO7 passive transmembrane transporter activity GO10 calcium ion binding |
| OG0000168 |
C. waltheriae ↓ T. diversipes ↑ |
Trp (Drosophila melanogaster) |
Cell Component GO1 ion channel complex GO2 transporter complex GO3 plasma membrane protein complex GO4 intrinsic component of plasma membrane GO5 integral component of plasma membrane Molecular Function GO1 channel activity GO7 passive transmembrane transporter activity |
| Sodium channels | |||
| OG0003129 |
C. waltheriae ↑ T. diversipes ↓ |
NaCP60E (Drosophila melanogaster) |
Cell component GO1 ion channel complex GO2 transporter complex GO3 plasma membrane protein complex GO4 intrinsic component of plasma membrane GO5 integral component of plasma membrane Molecular function GO1 channel activity GO7 passive transmembrane transporter activity |
| OG0002153 |
C. waltheriae ↑ T. diversipes ↓ |
unc80 (Drosophila melanogaster) |
Cell component GO1 ion channel complex GO2 transporter complex Molecular Function GO1 channel activity GO7 passive transmembrane transporter activity |
| Potassium channels | |||
| OG0004503 |
C. waltheriae ↓ T. diversipes ↑ |
KCNQ1 (Felis catus, Xenopus laevis) |
Cell component GO1 ion channel complex GO2 transporter complex GO3 plasma membrane protein complex GO4 intrinsic component of plasma membrane GO5 integral component of plasma membrane Molecular function GO1 channel activity GO3 potassium ion transmembrane transporter activity GO7 passive transmembrane transporter activity |
| OG0000260 |
C. waltheriae ↓ T. diversipes ↑ |
Sh (Drosophila melanogaster) |
Cell component GO1 ion channel complex GO2 transporter complex GO3 plasma membrane protein complex GO4 intrinsic component of plasma membrane GO5 integral component of plasma membrane Molecular function GO1 channel activity GO3 potassium ion transmembrane transporter activity GO7 passive transmembrane transporter activity |
| OG0004153 |
C. waltheriae ↑ T. diversipes ↓ |
KCNT1 (Homo sapiens) |
Molecular function GO1 channel activity GO3 potassium ion transmembrane transporter activity GO7 passive transmembrane transporter activity |
| OG0002734 |
C. waltheriae ↑ T. diversipes ↓ |
KCNK9 (Homo sapiens, Rattus norvegicus) |
Molecular function GO1 channel activity GO3 potassium ion transmembrane transporter activity GO7 passive transmembrane transporter activity |
| Chloride channel | |||
| OG0000326 |
C. waltheriae ↓ T. diversipes ↑ |
Grd (Drosophila melanogaster) |
Molecular function GO1 channel activity GO2 transmembrane signaling receptor activity GO6 GABA receptor activity GO7 passive transmembrane transporter activity GO8 molecular transducer activity |
| Ligand-gated ion channels | |||
| OG0000029 |
C. waltheriae ↓ T. diversipes ↑ |
Grik2 (Mus musculus, Xenopus laevis) |
Cell component GO1 ion channel complex GO2 transporter complex GO3 plasma membrane protein complex GO4 intrinsic component of plasma membrane GO5 integral component of plasma membrane Molecular function GO1 channel activity GO2 transmembrane signaling receptor activity GO3 potassium ion transmembrane transporter activity GO5 postsynaptic neurotransmitter receptor activity GO7 passive transmembrane transporter activity GO8 molecular transducer activity |
| OG0000962 |
C. waltheriae ↓ T. diversipes ↑ |
nAChRβ1 (Drosophila melanogaster) |
Cell component GO1 ion channel complex GO2 transporter complex GO3 plasma membrane protein complex GO4 intrinsic component of plasma membrane GO5 integral component of plasma membrane Molecular function GO1 channel activity GO2 transmembrane signaling receptor activity GO5 postsynaptic neurotransmitter receptor activity GO7 passive transmembrane transporter activity GO8 molecular transducer activity |
| G-protein coupled receptors | |||
| OG0002068 |
C. waltheriae ↓ T. diversipes ↑ |
GABBR1 (Homo sapiens, Mus musculus) |
Cell component GO3 plasma membrane protein complex GO4 intrinsic component of plasma membrane GO5 integral component of plasma membrane Molecular function GO2 transmembrane signaling receptor activity GO5 postsynaptic neurotransmitter receptor activity GO6 GABA receptor activity GO8 molecular transducer activity |
| OG0001556 |
C. waltheriae ↑ T. diversipes ↓ |
Gabbr2 (Mus musculus) |
Cell component GO3 plasma membrane protein complex GO4 intrinsic component of plasma membrane GO5 integral component of plasma membrane Molecular function GO2 transmembrane signaling receptor activity GO6 GABA receptor activity GO8 molecular transducer activity |
| OG0000063 |
C. waltheriae ↑ T. diversipes ↓ |
Octβ2R (Drosophila melanogaster) |
Molecular function GO2 transmembrane signaling receptor activity GO8 molecular transducer activity |
| OG0001943 |
C. waltheriae ↑ T. diversipes ↓ |
HTR2C (Mus musculus, Bos taurus) |
Molecular function GO2 transmembrane signaling receptor activity GO8 molecular transducer activity |
| OG0000814 |
C. waltheriae ↓ T. diversipes ↑ |
CG31760 (Drosophila melanogaster) |
Molecular function GO2 transmembrane signaling receptor activity GO8 molecular transducer activity |
| OG0001490 |
C. waltheriae ↓ T. diversipes ↑ |
Gr64f./Gr5a (Drosophila melanogaster) |
Molecular function GO2 transmembrane signaling receptor activity GO8 molecular transducer activity |
| G protein | |||
| OG0004442 |
C. waltheriae ↓ T. diversipes ↑ |
G-sα60A (Anopheles gambiae) |
Cell component GO3 plasma membrane protein complex |
| Translocases | |||
| OG0001155 |
C. waltheriae ↑ T. diversipes ↓ |
Atpα (Drosophila melanogaster) |
Cell component GO2 transporter complex GO3 plasma membrane protein complex GO4 intrinsic component of plasma membrane GO5 integral component of plasma membrane Molecular function GO1 channel activity GO3 potassium ion transmembrane transporter activity |
| OG0001472 |
C. waltheriae ↑ T. diversipes ↓ |
nrv2/nrv1 (Drosophila melanogaster) |
Cell component GO2 transporter complex GO3 plasma membrane protein complex GO4 intrinsic component of plasma membrane GO5 integral component of plasma membrane |
| OG0000864 |
C. waltheriae ↓ T. diversipes ↑ |
UQCRFS1 (Lagothrix lagotricha, Colobus polykomos) |
Molecular function GO1 channel activity |
| DNA-binding protein | |||
| OG0003803 |
C. waltheriae ↑ T. diversipes ↓ |
Hr38 (Drosophila melanogaster) |
Molecular function GO2 transmembrane signaling receptor activity GO8 molecular transducer activity GO11 sequence-specific DNA binding GO12 DNA binding |
| Low-density lipoprotein-receptor-related | |||
| OG0004128 |
C. waltheriae ↑ T. diversipes ↓ |
LRP6 (Homo sapiens, Mus musculus) |
Cell component GO3 plasma membrane protein complex Molecular function GO2 transmembrane signaling receptor activity GO8 molecular transducer activity |
| Cell adhesion molecules | |||
| OG0000727 |
C. waltheriae ↑ T. diversipes ↓ |
NRXN1 (Homo sapiens, Mus musculus) |
Cell component GO4 intrinsic component of plasma membrane GO5 integral component of plasma membrane Molecular function GO2 transmembrane signaling receptor activity GO8 molecular transducer activity GO10 calcium ion binding |
| OG0000165 |
C. waltheriae ↑ T. diversipes ↓ |
Stan (Drosophila melanogaster) |
Molecular function GO2 transmembrane signaling receptor activity GO8 molecular transducer activity GO10 calcium ion binding |
| Protein phosphatase | |||
| OG0000836 |
C. waltheriae ↓ T. diversipes ↑ |
Ptp69D (Drosophila melanogaster) |
Molecular function GO2 transmembrane signaling receptor activity GO8 molecular transducer activity |
| Tyrosine-protein kinase | |||
| OG0002698 |
C. waltheriae ↓ T. diversipes ↑ |
Abl (Drosophila melanogaster) |
Molecular function GO2 transmembrane signaling receptor activity GO8 molecular transducer activity |
The orthologs are represented by the ID of their respective orthogroups. Expression patterns of orthologs comparatively between C. waltheriae and T. diversipes are indicated by arrows: ↑ (upregulated) and ↓ (downregulated). GO hierarchical groups refer to CirGo terms as shown in Fig. 2.