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IFN-γ production and the IFN-γ/IFNγR/JAK/STAT pathway. By attaching to a cell-surface receptor made up of two subunits, IFNγR1 and IFNγR2, linked to JAK1 and JAK2, respectively, IFN- γ stimulates the JAK/STAT1 pathway. STAT1 gets phosphorylated, starting the transcription of genes.
