Table 3.
Coagulation and global test parameters of patients with severe yellow fever infection according to the outcome of bleeding and death.
| Characteristics | All patients |
Alive patients |
Deceased patients |
P valueb | |||
|---|---|---|---|---|---|---|---|
| (N = 21) |
(n = 17) |
(n = 4) |
|||||
| Minor bleeding |
Major bleeding |
P valuea |
Minor bleeding |
Major bleeding |
Major bleeding |
||
| (n = 7) | (n = 14) | (n = 7) | (n = 10) | (n = 4) | |||
| Coagulation proteins | |||||||
| Fibrinogen (mg/dL), median (IQR) | 315 (177-349) | 187 (128-277) | .08 | 315 (177-349) | 189 (143-322) | 157 (112-189) | .12 |
| FII (%), median (IQR) | 69 (42-115) | 54 (39-71) | .41 | 69 (42-115) | 52 (46-77) | 46 (36-54) | .43 |
| FV (%), median (IQR) | 103 (51-170) | 64 (30-134) | .24 | 103 (51-170) | 129 (76-146) | 31 (30-48) | .04 |
| FVII (%), median (IQR) | 68 (26-91) | 49 (7-76) | .31 | 68 (26-91) | 66 (37-85) | 8 (6-29) | .43 |
| FVIII (%), median (IQR) | 177 (106-278) | 110 (65-210) | .35 | 177 (106-278) | 135 (98-210) | 89 (54-237) | .19 |
| FIX (%), median (IQR) | 63 (28-111) | 30 (11-99) | .29 | 63 (28-111) | 64 (24-117) | 12 (6-13) | .03 |
| FX (%), median (IQR) | 60 (23-90) | 35 (23-81) | .67 | 60 (23-90) | 54 (34-86) | 25 (23-43) | .51 |
| Protein C (%), median (IQR) | 64 (52-82) | 60 (34-70) | .15 | 64 (52-82) | 57 (46-77) | 50 (31-67) | .44 |
| ROTEM parameters | |||||||
| CT (sec), median (IQR) | 644 (552-845) | 1087 (587-2283) | .07 | 644 (552-845) | 719 (368-1114) | 2326 (1898-2986) | .006 |
| CFT (min), median (IQR) | 261 (129-690) | 241 (142-911) | .35 | 261 (129-690) | 390 (136-671) | 543 (2-1085) | .96 |
| α-Angle (°), median (IQR) | 47 (28-65) | 37 (15-60) | .51 | 47 (28-65) | 43 (32-64) | 15 (12-15) | .04 |
| MCF (mm), median (IQR) | 54 (35-58) | 33 (21-61) | .47 | 54 (35-58) | 41 (29-65) | 23 (19-25) | .10 |
| Lysis 30 (%), median (IQR) | 100 (100-100) | 100 (100-100) | .43 | 100 (100-100) | 100 (100-100) | 100 (100-100) | .47 |
| Hypocoagulability | |||||||
| n (%) | 5 (71.4) | 14 (100) | .04 | 5 (71.4) | 10 (100) | 4 (100) | .07 |
CFT, clot formation time; CT, clotting time; F, factor; MCF, maximal clot firmness; ROTEM, rotational thromboelastometry.
P values were considered significant if P < .05.
a
Comparison between the 2 groups was performed using the Mann–Whitney U-test, considering alpha at 5%.
b
Comparison between the 3 groups was performed using the Kruskal–Wallis statistic test, considering alpha at 5%.