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. Author manuscript; available in PMC: 2024 May 30.
Published in final edited form as: Nat Rev Cancer. 2023 Jan 19;23(3):156–172. doi: 10.1038/s41568-022-00543-5

Figure 2. Regulation of acetyl-CoA metabolic enzymes.

Figure 2.

(A) Transcriptional and post-translational regulation of acetyl-CoA metabolic enzymes. (B) Impact of oncogenic, microenvironmental and systemic metabolic factors on regulation of acetyl-CoA metabolic enzymes (red, signals associated with oncogenic signaling, high nutrient availability and fatty acid synthesis; green, signals associated with high lipid availability and fatty acid oxidation, and may be linked to obesity-related cancers; blue, signals associated with nutrient stress-inducing adaptation within the tumor microenvironment, which may include fatty acid oxidation or fatty acid synthesis depending on the context). Each of these adaptations may support tumor growth and/or facilitate survival within the tumor microenvironment.