Table 4.

Association between baseline MRI measures and longitudinal change in disability

	Change in EDSS	% change 25FTW	% change 9HPTa	% change PASAT	% change SDMT
Total cortical lesion number	−0.015	0.516b,***	0.639b,***	−0.038	−0.014
Total cortical lesion volume	0.020	0.488b,***	0.686b,***	−0.130	−0.050
Leukocortical lesion number	−0.100	0.436b,***	0.437b,***	−0.302b,*	−0.009
Leukocortical lesion volume	0.028	0.516b,***	0.461b,***	−0.372b,*	0.049
Intracortical lesion number	0.017	0.310b,*	0.508b,***	0.000	−0.225
Intracortical lesion volume	0.044	0.270b,*	0.540b,***	−0.038	−0.235
Subpial lesion number	0.011	0.505b,***	0.636b,***	0.104	−0.015
Subpial lesion volume	0.023	0.416b,**	0.651b,***	0.049	−0.093
White matter lesion volume	−0.099	0.450b,***	0.123	−0.382b,**	−0.031
Spinal cord lesion number	−0.003	0.121	0.100	−0.109	0.207
Normalized brain volume	−0.065	−0.122	0.285	0.456b,*	−0.057
Normalized deep grey matter volume	−0.160	−0.355b,*	−0.122	0.408b,*	−0.190
Normalized cortical volume	0.114	0.246	0.455b,*	0.281	0.001
Normalized white matter volume	0.092	−0.156	0.189	0.438b,*	0.080

EDSS: Expanded Disability Status Scale.

25FTW: 25-foot timed walk.

9HPT: 9-hole peg test.

PASAT: Paced Auditory Serial Addition Test.

SDMT: Symbol Digit Modalities Test.

^aIn hand with greater worsening. Partial correlations, adjusted for age and sex.

^bSignificant after adjusting for false discovery rate.

^* P < 0.05.

^** P < 0.01.

^*** P < 0.001.