Table 5.

Baseline MRI measures in people with progression of disability versus stable disability

	Progression of disabilitya	No progression of disability	B b	P-valueb
Age (years)c	50 ± 9	48 ± 13	-	0.43
Cortical lesionsd
Total cortical lesion number	32, 87 (2–212)	14, 24 (0–142)	0.673	0.008*
Total cortical lesion volume (µl)	1010, 3162 (13–9888)	267, 854 (0–3539)	0.809	0.001*
Leukocortical lesion number	12, 26 (0–49)	5, 12 (0–67)	0.454	0.07
Leukocortical lesion volume (µl)	262, 921 (0–1709)	85, 236 (0–2818)	0.591	0.02*
Intracortical lesion number	2, 6 (0–10)	1, 3 (0–20)	0.441	0.08
Intracortical lesion volume (µl)	8, 23 (0–71)	2, 8 (0–65)	0.525	0.04*
Subpial lesion number	16, 50 (0–168)	6, 14 (0–114)	0.702	0.006*
Subpial lesion volume (µl)	285, 2038 (0–9660)	209, 496 (0–3131)	0.777	0.002*
White matter lesion volume (ml)c	10.4, 14.2 (1.5–63.1)	6.5, 12.0 (0.9–50.8)	0.206	0.42
Spinal cord lesion numberd	7, 5.5 (0–13)	4, 8 (0–19)	0.305	0.24
Normalized brain volume (ml)c
Whole brain	1468 ± 45	1479 ± 56	−0.035	0.59
Deep grey matter	67 ± 7	69 ± 6	−0.217	0.19
Cortex	659 ± 16	656 ± 24	0.343	0.13
White matter	560 ± 26	558 ± 31	0.091	0.97

^aOverall disability progression defined as an increase in Expanded Disability Status Scale (EDSS) of ≥1.0 for baseline EDSS <6.0 or ≥0.5 for baseline EDSS ≥6.0 or 20% increase in 25 foot timed walk or 20% increase in 9-hole peg test.

^bMultivariable general linear model adjusted for age and sex.

^cMean ± SD.

^dMedian, interquartile range (range).

^*Significant after adjusting for false discovery rate.