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. 2024 May 30;22:517. doi: 10.1186/s12967-024-05233-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — CircDCAF8 transmits regorafenib resistance by exosomes. A Cell viability of cells treated with different doses of regorafenib for 48 h. B Relative expression of circDCAF8 in regorafenib sensitive and resistant cells. C The knockdown efficiency of circCAF8 in regorafenib resistant cells were determined by qRT-PCR. D, E CCK8 and colony formation assays evaluated the proliferation of sh-circDCAF8 regorafenib resistant cells. F Exosomes secreted by regorafenib resistant cells were ingested by sensitive cells. Scale bar = 20 μm. G qRT-PCR was used to detect the relative expression of circDCAF8 in sensitive cells after incubation with exosomes from different sources. H CCK8 assay detected proliferation capacity in exosome-treated sensitive cells. I Regorafenib therapy or circDCAF8 knockdown could both inhibit the proliferation of the tumors formed in nude mice. J The weight of the subcutaneous tumor. K H&E and Ki67 staining of xenograft tumors. Scale bar = 50 μm. Data are presented as means ± SDs. In A-E, G, H, n = 3; in I-K, n = 6. (ns, not significant; *p < 0.05; **p < 0.01; ***p < 0.001)