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. 2024 May 30;22:520. doi: 10.1186/s12967-024-05347-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 12 — Nanoparticles delivering DTX for melanoma metastasis and growth suppression. A DTX-CSCD nanoparticles self-assemble, target tumors, and dispense medication in reaction to redox/enzymatic triggers. B Live tracking of DTX distribution in melanoma-bearing mice post intravenous delivery via the tail with Taxotere®, DTX-CSAD3, and DTX-CSCD3, averaged data as mean ± SD (n = 3). C Comparative anti-tumor effectiveness of normal saline (NS), Taxotere®, DTX-CSAD3, and DTX-CSCD3 nanoparticles in mice with B16F10 tumors, results expressed as mean ± SD (n = 5), with statistical significance indicated by *p < 0.05, ***p < 0.001, compared to the DTX-CSCD3 group. D Examination of lung tissue via H&E staining from B16F10 melanoma mice treated with various compounds, where yellow circles highlight areas of lung metastasis

(Reprinted with permission from [106])