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. 2024 May 30;22:520. doi: 10.1186/s12967-024-05347-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — DTX-loaded solid lipid nanoparticles Solid lipid nanoparticles encapsulating DTX. A The composition of SLN-DTX. B Release pattern of SLN-DTX at neutral (pH 7.4) and acidic (pH 5.0) conditions in PBS over a period of 10 days, presented as average ± standard error (****p < 0.0001). C Changes in tumor size in Balb/c mice bearing 4T1 tumors treated with SLN-DTX, DTX, Blank-SLN, and PBS, with significant distinctions noted against the PBS group (***p < 0.001; ****p < 0.0001). D Lung image. E Statistical evaluation of lung tumor nodules. F Microscopic examination of lung tissue, highlighting metastatic locations with black arrows and red dotted lines. Averages ± standard error are provided (**p < 0.01; ****p < 0.0001)

(Reprinted with permission from [80])