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. 2024 May 30;22:520. doi: 10.1186/s12967-024-05347-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — DTX-loaded NPs within liposomes. A Assessment of liposomal penetration into MCF-7 and MCF-7/ADR cells using confocal laser scanning microscopy (CLSM) after a 2-h exposure to different liposomal formulations, including free coumarin-6, TPGS-coumarin-6 liposome, PEG-coumarin-6 liposome, and DSPC-coumarin-6 liposome. The scale bar is set at 50 µm. The capacity of the various liposomal configurations to induce apoptosis in B MCF-7 cells and C MCF-7/ADR cells, with statistical significance denoted by *P < 0.05 when compared to TPGS-chol-liposome (n = 3)

(Reprinted with permission from [89])