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. 2024 May 30;22:520. doi: 10.1186/s12967-024-05347-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — DTX within Silver Nanoclusters. A Creation of fluorescent AgNCs embedded in Chitosan. B The oral bioavailability of DTX suspension versus DTX-Ag-NCPs was evaluated in rabbits (n = 5) by measuring blood levels at set times (via HPLC) following the administration of 10 mg/kg of each formulation. C The comparative in vitro effectiveness of DTX suspension, DTX-Ag-NCPs, and Ag-NCPs on the human breast cancer cell line MDA-MB-231 was assessed. D The impact on the organ to body weight ratio in Swiss albino mice was examined following the OECD 425 guidelines for acute oral toxicity, with tests conducted on DTX, DTX-Ag-NCPs, and Ag-NCPs. The error bar denotes the Mean ± S.D. from three separate trials

(Reprinted with permission from [97])