Fig. 9.

HSA nanoparticles loaded with DTX targeting non-small cell lung cancer. A Evaluation of DNP's effect against metastasis in vitro. (I) Assessment of PC9 cell adhesion following treatment with DNPs (DTX INJ) or DTX. (II) The rate of cell migration and (III) invasiveness derived from (IV). (IV) Photographic evidence of cells migrating or invading through matrigel-coated transwell barriers post-treatment with DNPs or DTX, stained with crystal violet and captured using a fluorescent microscope. Scale bar = 200 µm. B Assessment of DNP's antitumor activity in a live mouse model. (I) Tumor site count averages. (II) Survival rate monitoring of mice under treatment. (III) Quantification of lung H&E staining and tumor dimensions utilizing OLYMPUS OlyVIA software, with (IV) tumor areas highlighted by dotted black lines. Scale bar = 200 µm. Data represent means ± SD. Significance levels are indicated as *p < 0.05, **p < 0.01, and ***p < 0.001 between the groups indicated

(Reprinted with permission from [101])