Table 1.
DTX delivery for cancer therapy
| No | Material and Study model | Cell type | Target site | Encapsulation method | Key results | Conclusion | Refs. |
|---|---|---|---|---|---|---|---|
| 1 | PDLLA nanofiber-DTX-mice | 4T1 cell line | Breast cancer | Emulsion | In 4T1 cells, DTX /PDLLA nanofibers induced apoptosis. Biocompatibility of DTX/PDLLA nanofibers was observed after implantation in target site | Nanofibers composed of DTX and PDLLA may have tremendous potential for clinical applications requiring local chemotherapy | [53] |
| 2 | CNFs and CNTs-DTX-mitomycin C-in-vitro | DU-145 PCa cells | Prostate cancer | Cells were treated with drugs | reduced the viability of PCa cells that was more in the CNFs group and anti-tumor effects was observed | Carbon nanomaterials could reduce dosage, systemic adverse effects, and chemoresistance by local delivery of chemotherapeutics | [55] |
| 3 | PLA-PEO-PPO-PEO-PLA-DTX-mice | CT26 cells and L929 cells | Colon Cancer | Emulsion | Releasing of drugs slowly, increased apoptosis of tumor cells, and inhibited angiogenesis, and control of Cancer in the mice Colon | The microspheres, loaded with two drugs and made of nanofibers, hold promising potential for treating abdominal metastases in colorectal cancer | [57] |
| 4 | PGCL/PLGA-DTX, cabazitaxel-in-vitro | PC-3 and DU145 cells | Prostate cancer | Blending | Burst release of DTX than cabazitaxel and PGCL/PLGA + CTX was selected for anticancer analysis; decreased cell growth, good biocompatibility | Bioresorbable patches filled with cabazitaxel show promise as a drug delivery device for the treatment of prostate cancer | [59] |
| 5 | PVA-DTX -in-vitro | T47D cells | Oral cancer | Blending | Decreasing cell viability in the carrier system compared to the control group | Polymeric nanofibers can deliver anticancer drugs locally | [58] |
| 6 | Polycaprolactone-chitosan-DTX or doxorubicin-in-vitro | MCF-7 and T47-D | Breast cancer | Cells were treated with DTX | Increasing in markers related to mammary stem cell, sphere formation, inhibit differentiation of BCSC, rise in DTX-doxorubicin resistance | These scaffolds could be a good model for observing BCSC and how they react to anticancer drugs | [60] |
| 7 | Collagen-DTX and camptothecin-in-vitro | C4-2B Cells | Prostate cancer | Treating after cell culture | Microfibrous membrane showed better tumor microenvironment than other groups, formation of colonies like tumors, electrospun scaffolds indicated, cells on electrospun scaffolds indicated more resistance to both chemotherapy agents than other groups | This framework provides a controlled and reliable cell culture model useful for studies in cancer research and regenerative medicine | [61] |
| 8 | PCL/ZnO-DTX-in-vitro | Lung cancer cell line (A549) | Lung cancer | Blending | Constructs containing nanofibers and DTX indicated minimum toxicity to natural cells, promoted apoptosis of cancer cells | PCL + ZnO + DTX nanofibers can act as a targeted delivery method for the treatment of recurrence lung cancer | [48] |
| 9 | PDO/gelatin DTX, Cisplatin and Fluorouracil-mice | CD24 + and CD44 + cancer stem cells | In-vitro and in-vivo-Gastric cancer | Adding after implantation | In vitro and in vivo carcinogenesis increased without apoptosis | Depleting CD24 + and CD44 + cells made these medicines efficient stomach tumor treatment | [62] |
| 10 | PVA-lentinan and DTX-in-vitro | MCF-7 cells | Breast cancer | Blending | Breast cancer cell viability and the HER3 gene expression reduced in PVA/lentinan/DTX group than other groups | The use of lentinan, a natural substance, with a common chemical anticancer medicine and nano-drug delivery technology may be a viable cancer treatment | [24] |
Breast-cancer stem-like cells (BCSC), Poly Lactic-co-Glycolic Acid (PLGA), Poly(ethyleneoxide)–poly(propylene oxide)–poly(ethylene oxide) (PEO–PPO–PEO), Poly(glycolide-"-caprolactone) (PGCL), Poly(lactic acid) (PLA), Polycaprolactone (PCL), Polydioxanone (PDO), Polyvinyl alcohol (PVA), Zinc oxide (ZnO)