Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 May 29;23:186. doi: 10.1186/s12933-024-02224-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — Ferroptosis contributes to vascular calcification dynamics. VSMCs were treated with high phosphate and calcium levels to induce VSMC calcification in vitro, and C11-BODIPY 581/591 was used to analyse fluorescent cytosolic and lipid ROS (A). Ultrastructural changes in muscle cells were examined using electron microscopy (B). Heatmap illustrating Differentially Expressed Genes (DEGs) between control and calcification groups in the GSE 211722 dataset (C). Volcano plots showing DEGs (D). Venn diagram illustrating overlapping DEGs identified in the two datasets (E). Gene Ontology enrichment analysis (biological processes, molecular functions, and cellular components) was conducted for the hub genes (F-H). Pathway analysis based on the Kyoto Encyclopaedia of Genes and Genomes was performed for hub genes (I). A Protein–Protein Interaction (PPI) network analysis was conducted for hub genes (J)