Table 2.
Results of univariate mendelian randomization analyses on sarcopenia phenotypes and osteoarthritis in knee and hip joints
| Outcome | Exposure | Method | SNP(n) | β | SE | OR (95%CI) | P- value |
|---|---|---|---|---|---|---|---|
| KOA | ALM | MR-Egger | 503 | 0.142 | 0.075 | 1.152(0.995–1.335) | 0.059 |
| Weighted median method | 503 | 0.124 | 0.034 | 1.132(1.059- 1.210) | 2.59 × 10–4 | ||
| Inverse variance weighting | 503 | 0.140 | 0.029 | 1.151(1.087- 1.218) | 1.19 × 10–6 | ||
| Simple model | 503 | -0.062 | 0.130 | 0.940(0.728- 1.214) | 0.635 | ||
| Weighted model | 503 | 0.176 | 0.115 | 1.193(0.953- 1.493) | 0.125 | ||
| LHG | MR-Egger | 4 | -0.001 | 0.231 | 0.999(0.635- 1.573) | 0.997 | |
| Weighted median method | 4 | 0.114 | 0.105 | 1.121(0.913- 1.376) | 0.276 | ||
| Inverse variance weighting | 4 | 0.195 | 0.097 | 1.215(1.004- 1.470) | 0.046 | ||
| Simple model | 4 | 0.067 | 0.146 | 1.070(0.803- 1.425) | 0.676 | ||
| Weighted model | 4 | 0.067 | 0.152 | 1.070(0.794- 1.442) | 0.688 | ||
| UWP | MR-Egger | 14 | -1.172 | 1.253 | 0.310(0.027- 3.611) | 0.368 | |
| Weighted median method | 14 | -0.670 | 0.375 | 0.512(0.246- 1.067) | 0.074 | ||
| Inverse variance weighting | 14 | -0.687 | 0.278 | 0.503(0.292- 0.867) | 0.013 | ||
| Simple model | 14 | 0.240 | 0.820 | 1.271(0.255- 6.349) | 0.774 | ||
| Weighted model | 14 | 0.265 | 0.736 | 1.303(0.308- 5.508) | 0.725 | ||
| HOA | ALM | MR-Egger | 500 | 0.100 | 0.094 | 1.105(0.919- 1.327) | 0.288 |
| Weighted median method | 500 | 0.185 | 0.042 | 1.203(1.108- 1.307) | 1.14 × 10–5 | ||
| Inverse variance weighting | 500 | 0.166 | 0.035 | 1.181(1.103- 1.265) | 2.05 × 10–6 | ||
| Simple model | 500 | 0.346 | 0.146 | 1.414(1.062- 1.881) | 0.018 | ||
| Weighted model | 500 | 0.292 | 0.112 | 1.339(1.076- 1.667) | 0.009 | ||
| LHG | MR-Egger | 10 | 0.810 | 0.451 | 2.248(0.928- 5.442) | 0.110 | |
| Weighted median method | 10 | 0.059 | 0.101 | 1.061(0.870- 1.294) | 0.561 | ||
| Inverse variance weighting | 10 | 0.187 | 0.144 | 1.206(0.909- 1.600) | 0.194 | ||
| Simple model | 10 | 0.078 | 0.171 | 1.082(0.774- 1.512) | 0.657 | ||
| Weighted model | 10 | 0.078 | 0.168 | 1.082(0.778- 1.503) | 0.651 | ||
| UWP | MR-Egger | 16 | -2.496 | 1.367 | 0.082(0.006- 1.202) | 0.089 | |
| Weighted median method | 16 | -0.825 | 0.449 | 0.438(0.182- 1.056) | 0.066 | ||
| Inverse variance weighting | 16 | -0.825 | 0.337 | 0.438(0.226- 0.849) | 0.014 | ||
| Simple model | 16 | -0.769 | 0.812 | 0.463(0.094- 2.278) | 0.359 | ||
| Weighted model | 16 | -0.719 | 0.813 | 0.487(0.099- 2.396) | 0.390 |
KOA Knee osteoarthritis, HOA Hip osteoarthritis, ALM Appendicular lean mass, LHG Low hand grip, UWP Usual walking pace