Table 4.

Results of multivariable mendelian randomization analyses on sarcopenia phenotypes and osteoarthritis in knee and hip joints

Outcome	Exposure	Method	OR (95%CI)	P-value
KOA	ALM	MR-Egger	1.273(1.130- 1.433)	6.69 × 10–5
		Weighted median method	1.327(1.219- 1.444)	6.13 × 10–11
		Inverse variance weighting	1.323(1.224- 1.431)	2.07 × 10–12
		MR-Lasso	1.325(1.250- 1.405)	2.90 × 10–21
	LHG	MR-Egger	1.159(1.042- 1.290)	0.007
		Weighted median method	1.182(1.061- 1.317)	0.002
		Inverse variance weighting	1.161(1.044- 1.292)	0.006
		MR-Lasso	1.194(1.100- 1.295)	2.11 × 10–5
	UWP	MR-Egger	0.497(0.281- 0.878)	0.016
		Weighted median method	0.534(0.303- 0.940)	0.030
		Inverse variance weighting	0.511(0.290- 0.899)	0.020
		MR-Lasso	0.527(0.350- 0.794)	0.002
HOA	ALM	MR-Egger	1.097(0.960- 1.253)	0.175
		Weighted median method	1.248(1.143- 1.364)	8.62 × 10–7
		Inverse variance weighting	1.245(1.149- 1.348)	7.65 × 10–8
		MR-Lasso	1.234(1.162- 1.311)	8.82 × 10–12
	UWP	MR-Egger	0.762(0.387- 1.502)	0.432
		Weighted median method	0.817(0.425- 1.571)	0.545
		Inverse variance weighting	0.825(0.419- 1.626)	0.579
		MR-Lasso	0.918(0.562- 1.499)	0.732

KOA Knee osteoarthritis, HOA Hip osteoarthritis, ALM Appendicular lean mass, LHG Low hand grip, UWP Usual walking pace