Table 1.
Linear regression analysis for age of onset and disease duration (data from deceased patients, n > 5)
| Variant | n | Linear regression | Age of onset | Disease duration | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Formula | R | P value | Mean (years) | variance | skewness | Mean (months) | variance | skewness | ||
| Total | 490 | y = –1.01x + 112.03 | –0.18 | 0.00005 | 49.22 ± 13.73 | 188.55 | 0.04 | 56.17 ± 76.15 | 5799.42 | 2.70 |
| A5V | 36 | y = 0.02x + 13.78 | 0.03 | 0.85311 | 48.12 ± 13.08 | 170.98 | –0.57 | 12.90 ± 7.80 | 60.77 | 0.96 |
| D91A_homa | 34 | y = –3.41x + 308.60 | –0.53 | 0.00132 | 50.34 ± 15.08 | 227.54 | 0.53 | 136.86 ± 97.38 | 9482.72 | 0.74 |
| I114T | 21 | y = –1.54x + 131.21 | –0.41 | 0.06456 | 57.33 ± 9.39 | 88.19 | –0.80 | 45.10 ± 35.28 | 1244.59 | 1.18 |
| D91A | 19 | y = –3.38x + 300.71 | –0.58 | 0.00863 | 51.73 ± 13.86 | 192.05 | 0.47 | 125.71 ± 80.26 | 6441.54 | 0.34 |
| L145F | 19 | y = –6.40x + 450.66 | –0.64 | 0.00317 | 49.80 ± 15.57 | 242.52 | –0.27 | 130.81 ± 155.84 | 24287.06 | 1.78 |
| G42S | 17 | y = –0.10x + 17.39 | –0.25 | 0.32762 | 47.82 ± 11.01 | 121.20 | –0.80 | 12.71 ± 4.27 | 18.21 | –0.13 |
| L85F | 16 | y = 0.77x + 23.03 | 0.30 | 0.25493 | 41.50 ± 11.96 | 143.12 | –0.27 | 55.12 ± 30.59 | 935.98 | 1.28 |
| c.358–10T>G | 11 | y = 0.38x + 10.31 | 0.23 | 0.49288 | 62.09 ± 12.71 | 161.54 | 0.76 | 34.00 ± 20.92 | 437.82 | 0.77 |
| C112Y | 10 | y = 1.29x – 16.29 | 0.73 | 0.01711 | 48.95 ± 11.94 | 142.53 | 0.24 | 46.77 ± 21.14 | 447.02 | 0.74 |
| H47R | 8 | y = –4.78x + 427.05 | –0.57 | 0.13950 | 46.50 ± 8.48 | 71.86 | –0.26 | 201.00 ± 70.96 | 5034.75 | –0.68 |
| K4E | 8 | y = 1.88x – 28.51 | 0.29 | 0.48474 | 58.38 ± 8.20 | 67.23 | 0.37 | 81.00 ± 52.90 | 2798.25 | 0.53 |
| I113T | 8 | y = 0.03x + 20.59 | 0.02 | 0.96751 | 64.88 ± 8.10 | 65.61 | –0.55 | 22.62 ± 14.63 | 213.92 | 1.59 |
| N87S | 8 | y = –1.65x + 156.15 | –0.93 | 0.00079 | 57.62 ± 17.80 | 316.73 | –0.35 | 61.12 ± 31.53 | 994.36 | 0.37 |
| C7S | 8 | y = –3.44x + 262.09 | –0.69 | 0.05687 | 51.12 ± 10.06 | 101.11 | 0.35 | 86.00 ± 50.00 | 2500.00 | 0.61 |
| H44R | 7 | y = 0.91x – 32.81 | 0.83 | 0.02214 | 50.55 ± 8.67 | 75.21 | 1.05 | 15.40 ± 9.58 | 91.72 | 1.56 |
| R116G | 6 | y = –0.60x + 52.51 | –0.75 | 0.08710 | 55.17 ± 11.87 | 140.81 | –0.51 | 19.45 ± 9.51 | 90.35 | 0.52 |
| L127S | 6 | y = –1.66x + 168.62 | –0.74 | 0.09561 | 52.50 ± 15.48 | 239.58 | –0.05 | 81.33 ± 34.98 | 1223.89 | –0.22 |
| G94S | 6 | y = 2.22x – 25.25 | 0.68 | 0.14102 | 53.33 ± 12.76 | 162.89 | –0.82 | 93.00 ± 41.90 | 1756.00 | 0.12 |
| G148D | 6 | y = 0.13x + 7.76 | 0.26 | 0.61584 | 44.83 ± 10.02 | 100.47 | 0.50 | 13.80 ± 5.15 | 26.53 | 0.96 |
| G128Gfs*7 | 6 | y = 0.73x – 26.10 | 0.67 | 0.14906 | 63.00 ± 8.62 | 74.33 | –0.17 | 19.67 ± 9.41 | 88.56 | –0.40 |
| S135N | 6 | y = 0.34x + 19.97 | 0.11 | 0.83014 | 57.13 ± 14.67 | 215.09 | 0.47 | 39.17 ± 43.33 | 1877.81 | 1.35 |
| L107V | 6 | y = 1.51x – 35.45 | 0.46 | 0.35536 | 39.14 ± 7.13 | 50.81 | –0.22 | 24.40 ± 23.20 | 538.42 | 1.50 |
aAs most SOD1-related ALS patients are heterozygotes, ALS patients with SOD1 homozygotes are designated as "variant_hom"