Figure 2.

Kaplan-Meier curves: survival without therapeutic failure dependent on degree of mucosal healing achieved at follow-up endoscopy. Treatment failure defined as the composite end-point of: biological switch or discontinuation for active disease, corticosteroid use, CD-related admission or surgery (A) endoscopic remission: absence of ulceration (B) endoscopic remission: SES-CD $\le 2$ (C) endoscopic response: greater than 50% reduction in SES-CD (D) combined remission: SES-CD $\le 2$ and HBI <5. HBI, Harvey Bradshaw Index; SES-CD, Simple Endoscopic Score for Crohn’s Disease.