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. Author manuscript; available in PMC: 2024 Jul 6.
Published in final edited form as: Mol Cell. 2023 Jun 12;83(13):2206–2221.e11. doi: 10.1016/j.molcel.2023.05.022

Figure 7. H3K27cr represents a distinct chromatin state for gene transcriptional repression.

Figure 7.

Schematic illustration of a “Three-phase traffic light system” model describing three different H3K27 modifications as distinct chromatin states for gene transcription, i.e. H3K27me3 (Stop) marks for transcriptional silencing, H3K27cr (Pause) for transcriptional repression, and H3K27ac for transcriptional activation (Go). As illustrated for p21 and other GAS41 target genes such as those validated in Figure 6H, H3K27cr-directed gene transcriptional repression operates through selective recognition of H3K27cr by the YEATS domain of GAS41 in complex with MYC and SIN3A/HDAC1 co-repressor complex in chromatin.