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. 2024 May 21;13(5):bio060269. doi: 10.1242/bio.060269

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© 2024. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Ouabain inhibits anterior CNS development in Xenopus embryos. (A-B) Incubation of Xenopus embryos at the 32-cell stage in 10 μM Ouabain for 7 min results in embryos with a ventralized (small head) phenotype. A, anterior; P, posterior. (A′-B′) Ouabain incubation reduced the pan-neural marker sox2 in Xenopus embryos. (A″-B″) Ouabain incubation reduces the forebrain and midbrain marker Otx2 in Xenopus embryos (arrowhead). (A‴-B‴) Ouabain incubation reduces the eye marker Rx2a in Xenopus embryos. The numbers of embryos analyzed were as follows: A: 130, 100%; A′: 138, 97%; five independent experiments; A′: 32, 100%; B′: 36; 97%; A″: 32, 100%; B″: 28, 92%; A‴: 30, 100%; B‴: 27, 93%. Scale bar: 500 μm.