Scheme 2.

Ligand and reaction condition optimization for the stitching of 1,3-C(sp³)–H bonds and 1-bromo-2-iodoarenes.^a,b

^aConditions: 8 (0.15 mmol), 9 (0.10 mmol), Pd(CH₃CN)₄(BF₄)₂ (10 mol%), Ligand (L) (10 mol%), AgOAc (2.0 equiv), HFIP (0.5 mL), 80 °C, 48h. ^bYields were determined by ¹H NMR analysis of an unpurified product mixture using CH₂Br₂ as an internal standard.